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Seminars 2009

Tuesday, December 15
Jason Moore, Hendrickson Laboratory
Department of Biochemistry and Molecular Biophysics
“Structural Biology of Signaling in the TorT-TorS Histidine Kinase Receptor Complex”

Tuesday, November 24
Philip Effraim, Cornish Laboratory
Department of Chemistry
“Natural amino acids do not require their native tRNAs for efficient selection by the ribosome”

Tuesday, October 27
Jonathan Bronson, Wiggins Laboratory
Department of Applied Physics and Applied Mathematics
“Learning Rates and States from Biophysical Time Series: A Bayesian Approach to Model Selection and Single-Molecule FRET Data”


CMOS++: Integrated circuit design for life science applications

Prof Ken Shepard
Electrical Engineering
Columbia University

Tuesday, October 6, 12:00 PM
Room 700 Fairchild Hall

Abstract
Integrated circuits based on complementary metal-oxide-semiconductor (CMOS) technology have been the engine of the revolution in computation and communication experienced over the last 40 years. This talk will survey on-going research in my group to find new applications of integrated circuits involving direct interfaces with biological or biomolecular systems. This includes solid-state nanopores for DNA sequencing with integrated preamplifiers, ATP-power integrated circuits, piezoelectric mass-based sensors for protein assays, high-frame-rate imagers for fluorescence lifetime imaging microscopy (FLIM), integrated ptentiostatic arrays for biomolecular analysis, and chips that interface directly with neural tissue.

 

Reflections on Technology, Innovation, Entrepreneurship, and Life

Prof. Ed Zschau
Princeton University

Friday, February 20, 11:00 AM
Davis Auditorium
Schapiro Research Building

Biography

Ed Zschau is Professor at Princeton University in the Departments of Electrical Engineering, Operations Research and Financial Engineering, and in the Center for Innovation in Engineering Education. Prior to his current post at Princeton, from 1997-2000, he was Professor of Management at the Harvard Business School and a Visiting Professor at Princeton University.

Zschau's business experience is extensive. He founded and served from 1968-1981 as CEO of System Industries, a computer products company.

In 1987, after his narrow defeat for California's United States Senate seat, Zschau became a general partner of Brentwood Associates, a Los Angeles-based venture capital firm, and in 1988, he was elected Chairman and CEO of Censtor Corp., a company which had been founded by Brentwood to develop advanced magnetic recording components for disk drives. He was recruited from Censtor in April 1993 by Lou Gerstner to serve as General Manager of the IBM Storage Systems Division until July 1995.

He has an A.B. degree (cum laude) in philosophy from Princeton University and M.B.A., M.S. (statistics), and Ph.D. degrees from Stanford University.


Analysis and self-assembly of DNA nanotubes

RiSheng Wang
Department of Chemistry
New York University

Wednesday, January 21, 11:00 AM
Interschool Lab, 750 CEPSR
Schapiro Research Building

Abstract

DNA nanotubes are cylinder-like structures which are useful to as sheaths around rod-like species such as carbon nanotubes or biological systems. DNA six-helix nanotubes are assembled from two half-tubes through specifically designed lateral cohesive interactions. A seventh DNA helix is attached to the inside of one of the half-six-helix domains and then encapsulated within the middle of the six-helix bundle sheath by joining two half-tubes together. It is easy to obtain such sheathing by joining two components around an object. Interior hydrophobic DNA six-helix nanotubes are constructed by using methyl DNA in which anionic phosphate backbone was replaced with neutral methyl phosphonate linkages.The formation of these tubes is demonstrated by gel electrophoresis and visualized by Atomic Force Microscopy (AFM).

Nylon nucleic acid is a ladder polymer in which one rail is composed by a phosphodiester backbone and the other by a polyamide similar in structure to the polyamide nylon. The stability and structure of nylon nucleic acid duplexes with complementary DNA and RNA strands was examined by UV-Vis and CD spectroscopy. Thermal denaturing studies revealed that the amide linkage significantly enhanced the binding affinity of nylon nucleic acids.